Christopher Williams, PhD

Associate Professor of Pharmacology

Chair, Division of Basic Pharmaceutical Sciences

Dr. 威廉姆斯是e世博esball大学药学院的副教授和基础药物科学系主任. As an undergraduate, 他在新奥尔良的南方大学接受培训，并获得生物学学士学位. 作为杜兰大学的博士生，他在攻读药理学博士学位的同时研究了HIV-Tat蛋白对造血分化和趋化因子受体表达的影响. As a postdoctoral fellow in the Tulane Cancer Center, Dr. Williams研究了乳腺癌进展和耐药过程中的激酶和核受体信号串扰. 后来，他加入了e世博esball大学药学院，担任药理学助理教授，并继续致力于开发新的乳腺癌治疗靶点, with an emphasis on modulation of nuclear receptor signaling. Throughout his career, Dr. 威廉姆斯一直致力于指导生物医学科学领域代表性不足的少数民族学生/科学家. 他指导过的学生/科学家都成为了终身教职员工, pharmacists, physicians and research fellows. 他继续致力于开发项目，以扩大e世博esball大学毕业生在生物医学研究领域的机会.

Education: 美国杜兰大学癌症中心内分泌相关癌症信号研究博士后 

PhD in Pharmacology, Tulane University

BS, Biology Southern University at New Orleans

Teaching Areas: Basic Principles of Pharmacodynamics and 

药物动力学，毒理学，自主神经系统药理学， Pharmacology of antineoplastic drugs, antirheumatic drugs,antithrombotic drugs, antihyperlipidemic drugs.

Research Interests: Dr. 威廉姆斯的研究重点是发现治疗乳腺癌的新方法.  Specifically, the lab studies t蛋白激酶CK2抑制对乳腺癌中雌激素信号的影响, 前提是CK2抑制剂可以作为内分泌治疗难治性癌症患者的替代疗法.  该实验室正在研究孤儿核受体NR4A2/NURR1在乳腺癌预后中的作用, 作为预防乳腺癌的潜在治疗靶点.  Studies are also underway to elucidate the m抗糖尿病双胍类化合物抗肿瘤作用的分子机制，如 metformin and phenformin, 破坏乳腺癌微环境中的炎性自分泌和旁分泌信号.  Dr. Williams得到了NIH、海军研究办公室、LCRC和RCMI的支持.  Additionally, he has served as mentor for students in the COE, RISE, MARC, UNCF STEM Scholars, McNair Scholars, and LS-LAMP programs for undergraduate research.

Selected Publications:

Christopher Williams, June G. Allison, Luis Marrero, Gregory A. Vidal, and Frank E. Jones. ERBB4受体酪氨酸激酶通过作为STAT5A核伴侣调节表达 Journal of Cell Biology. 167(3):469-78, 2004 Nov 8.

Christopher  Williams, Debasis Mondal, Krishna Agrawal《e世博esball》 Experimental Biology & Medicine. 230(11):872-84, 2005 

Debasis Mondal, Christopher  Williams, Krishna Agrawal《e世博esball》 Experimental Biology & Medicine. 230(9):631-44, 2005 Oct. 

Christopher Williams, Diane Clark, Tamika Duplessis, and Frank E Jones. ErbB4通过调节丝氨酸和磷酸酪氨酸残基的磷酸化来调节STAT5a的转录活性. Journal of Biological Chemistry. 280(25):24175-80, 2005 Jun 24

Yun Zhu, Lacey Sullivan, Sujit Nair, Christopher Williams,  Arvind, Pandy  Luis Marrero, Ratna Vadlamudi,  雌激素诱导的ERBB4/HER4对雌激素受体的协同调节在乳腺癌中建立促进生长的自分泌信号通路.” Cancer Research 66(16) 7991-7998 2006

George P. Skliris, Brian G. Rowan, Mariam Al-Dhaheri, Christopher Williams, Sandy Troup, Sanela Begic, Michelle Parisien, Peter H. Watson and Leigh C. Murphy，《e世博esball》，《e世博esball》 2009 Dec;118(3):443-53

Leigh Murphy, Georgios Skliris, Brian Rowan, Mariam Al-Dhaheri， Christopher Williams, Carla Penner, Snady Troup, Senela Begic, Michelle Parisien, “雌激素受体磷酸化形式与人类乳腺癌的相关性 in vivo” 中国生物医学工程学报，2009,32 (1):444 - 444

Christopher Williams, Aninda Basu, Latonya Carrier, Carolyn Smith, 雌激素受体α新磷酸化位点:受体依赖基因表达和蛋白激酶CK2磷酸化的影响，BMC Biochem. 2009 Dec 31;10:36.

Melissa Heard, Claude V. Main, Benjamin E. Morehead, Marius C. Hoener, Tri Q. Nguyen, Christopher C. Williams, Brian G. Rowan, Chris R. Gissendanner“一个功能性的NR4A核受体dna结合域是器官发育所必需的 C. elegans” Gen. 2010 Aug;48(8):485-91

Tamika T. Duplessis, Christopher C. Williams, Steven M. Hill, and Brian G. Rowan，《e世博esball》, Endo 2011 152: 2517-2526

Brandy Huderson, Tamika Duplessis, Christopher  Williams, Henry Segar, Steven Hill, Brian Rowan, “稳定抑制特异性雌激素受体α (ERα)磷酸化可以促进生长, MCF-7乳腺癌细胞中雌二醇信号的迁移/侵袭和破坏.” Endo 2012, 153:4144-59.

肖恩·D·洛皮斯，布列塔尼·A·辛格尔顿，塔米卡·T·杜普莱西斯，拉托尼亚·杰克逊，布莱恩·G·罗文和 Christopher C Williams “孤儿核受体NURR1在乳腺癌中的双重作用.” BMC Cancer 2013 13:139

Christopher C. Williams, Brittany A. Singleton, Shawn D. Llopis, Elena Skripnikova “二甲双胍在乳腺癌中诱导衰老相关的基因特征.” J Health Care Poor Underserved 2013, 24(1 Suppl):93-103.

Syreeta L. Tilghman, Ian Townley, Qiu Zhong, Patrick P. Carriere, Jin Zou, Shawn D. Llopis, Lynez C. Preyan, Christopher C. Williams, Elena Skripnikova, 张强，王广弟，“乳腺癌获得性来曲唑耐药的蛋白质组学特征:抑制雌激素信号和增加细胞运动和侵袭性。.” Mol Cell Proteomics 2013 12: 2440-2455

马龙·威廉姆斯，阮图，帕特里克·卡里尔，西瑞塔·蒂尔曼， Christopher Williams. 蛋白激酶CK2表达预测ERα依赖性乳腺癌的复发生存, and Modulates ERα Expression in Vitro.”  Int J Environ Res Public Health. 2015 Dec 22;13(1):ijerph13010036. 

Chandler Schexnayder, Kiera Broussard, Demitrius Onuaguluchi, Anthony Poché A, Mohmen Ismail, LeFontae McAtee, Shawn Llopis, Amber Keizerweerd, Harris McFerrin, Christopher Williams. 二甲双胍通过抑制MDA-MB-231乳腺癌细胞中的ROS产生和COX2表达来抑制迁移和侵袭.” Int J Mol Sci. 2018 Nov 21;19(11). pii: E3692.